R&D

Animal Experiment

Animal Experiment

These are some findings from the animal experiment
01. There was no difference in the amount of collagen synthesis between PDO, PCL, and PLLA.
02. The level of foreign body reaction and collagen formation is in proportion to the thread surface contacting the tissues.
03. Cavern has more contact surface than other threads and thus, forms more collagen.
04. The more thread there is in the target area, the easier the formation of collagen network.
05. Excessive threads may worsen the inflammatory reaction around them.
06. Considering price and convenience of use, PDO may be the most efficient option.
07. The more the collagen, the more the volume.
Thread
Number of Rat
1 Week
2 Weeks
4 Weeks
8 Weeks
12 Weeks
PLLA Mono 5-0
9
1
1
2
2
3
PCL Mono 5-0
9
0
1
2
2
4
PDO Mono 5-0
8
0
1
1
0
1
PDO Mono 1-0
9
0
1
2
2
4
PDO Cavern 5-0
9
0
2
2
2
2
4 Weeks
12 Weeks
Cavern itself has high thread volume and as more surface area comes into contact with the tissues,
a large amount of collagen is synthesized.
Mono Type x 100
Cavern Type x 100
Animal experiment is on processing to prove to collect not only outside but also inside of CAVERN.